The axis of P.N.E.I includes four biological systems that operate in one: The Psycho-Neuro-Endocrine-Immune.

Regulation of PNEI means reprogramming of the organism in two directions: the psychosomatic and the somatopsychic axis and is considered the nucleus of the Natural Regulating Medicine.

Specifically, emotional and mental data together with social situations are connected together and via the central nervous system and endocrine glands with the endocrine and immune system regulate the psychic and immunological health of every human.

It has been proven that different personal experiences and emotions can be connected with the immune system and this with endocrine so the emotional trauma is getting translated into molecular level resulting in the disease. (Neuro-immunological connections: Felten et al., 1987; Endocrino-immunmological connections: Blalock, 1984).

Off course, there is not yet scientific proof that thought can cure immunological diseases (Relman & Angell, 2002). A published paper suggests various psychosomatic factors that can later response, evolutions and recurrence of immunological diseases (Taylor, 1999).

The issues that can influence the immune system are the following:

  • Age
  • Genetic malfunctions
  • Infectious diseases
  • Diet
  • Chemotherapy
  • Radiation
  • Allergies
  • Stress = disturbance of PNEI

Based on the disturbance of PNEI in a chronic disease, different individualized supplements can be used in different combinations in order to assist in detoxifying and symptomatic therapy of the off balance PNEI.