PRP Scientific Research Protocol for Uses and Applications

Within the framework of scientific research, Konstantinion Research Center implements the use of Rich Plasma Autologous Plasma (PRP) to improve and / or possibly cure chronic inflammatory diseases and chronic lesions of the musculoskeletal system with natural biological way and no side effects.

The center applies two high-density or non-dense PRP methodologies depending on the manner and site of application after receiving a similar amount of peripheral venous blood. The application of PRP is done with fine needles at the point of injury or degeneration following a specific design and injection technique by experienced physicians, completely painless.

It should be noted that complete biochemical and immunological testing will be performed at the request of the patient, with emphasis on the investigation of cytokines associated with the particular inflammation or condition following blood sampling or taking of biological fluid.
What is PRP and what does it consist of and what biochemical functions does it benefit.

Specially treated platelet-rich plasma (PRP) is biological material obtained by the patient himself enriched in platelets and other cells such as stem cells and endogenous proteins. This serum produced has no red blood cells, white blood cells, and has about five times the density of platelets from whole blood and a large number of growth factors such as VEGF, TGF, IGF-1, IGF-2, interleukins, etc., substances that have growth stimulants and other stimulants. The detailed content of the substances varies from method to method but in general the goal is the same: rebuilding or regenerating the tissues used, speeding up the healing process, suppressing inflammation and generally changing the local environment for the benefit of healthy tissues.

Platelet-rich plasma is used in medicine in a very broad field. Indicatively,  its applications contribute  in Neurology, Dermatology, Plastic Surgery, Dentistry, Cardiology, Rheumatology, and especially in Orthopedics. Large clinical studies have already been carried out and several are still ongoing, with good results in tendinitis, cartilage injuries, osteoarthritis and orthopedic surgery in particular arthroscopic. The infusion of these substances into the worn and irritated tendons, in joints with gross lesions either from injury or from osteoarthritis, in connective lesions as well as during surgery in the suture of soft tissues (muscles, tendons, ligaments) process, improve symptoms and accelerate treatment where possible. Repeated injections are usually required, the number of which is determined by the condition and the method of treatment.

A great advantage of the method is the easy availability and complete compatibility of the material as it is obtained by the patient himself, the quick and easy procedure of taking and injecting it, the minimal side effects and the low cost. Also, because it is a biological treatment it works for long term without requiring high repeatability as with medicines, which have many side effects.

The applications of PRP are as follows:
1) Osteoarthritis 2) Meniscus rupture
3) Epicondylitis 4) Tendonitis
5) Muscle strains and ligament stretches
6) Achilles tendon rupture 7) Knee and ankle sprains
8) Tendonitis 9) Adduction-quadriceps tendencies
10) Endopathies 11) Shoulder tendons
12) Facial regeneration 12) Improvement of hair loss


  Borrione P, Gianfrancesco AD, Pereira MT, Pigozzi F (2010). «Platelet-rich plasma in muscle healing». Am J Phys Med Rehabil 89 (10): 854–61. doi:10.1097/PHM.0b013e3181f1c1c7. PMID 20855985.

  Yu W, Wang J, Yin J (2011). «Platelet-Rich Plasma: A Promising Product for Treatment of Peripheral Nerve Regeneration After Nerve Injury». Int J Neurosci 121 (4): 176–180. doi:10.3109/00207454.2010.544432. PMID 21244302.

  Marx RE (2004). «Platelet-rich plasma: evidence to support its use». Journal of Oral and Maxillofacial Surgery 62 (4): 489–96. doi:10.1016/j.joms.2003.12.003. PMID 15085519.

  Dohan Ehrenfest DM, Rasmusson L, Albrektsson T (2009). «Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)». Trends in Biotechnology 27 (3): 158–67. doi:10.1016/j.tibtech.2008.11.009. PMID 19187989.

  Gonshor A (2002). «Technique for producing platelet-rich plasma and platelet concentrate: background and process». The International Journal of Periodontics & Restorative Dentistry 22 (6): 547–57. PMID 12516826.